Instance ID11068
Regular ExpressionPPxY
Motif InstancePPVY
Bait Uniprot AccessionP05627
Bait Uniprot IdentifierJUN_MOUSE
Bait Gene NameJun
Bait OrganismMus musculus (Mouse)
Sequence Position167-170
Critical ResiduesP4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Ubiquitinase assay; Co-IP; Colocalization; Mutation analysis
Interaction ID21068
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16901904, 15469925, 11828324
CommentsThe PPXY motif of mouse Proto-oncogene c-Jun that binds to the WW domain of mouse E3 ubiquitin-protein ligase Itch which targets Jun for lysosomal degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)