Instance ID11072
Regular Expressionxxx([ST])Px
Motif InstanceEAASPR
Bait Uniprot AccessionQ80Z64
Bait Uniprot IdentifierNANOG_MOUSE
Bait Gene NameNanog
Bait OrganismMus musculus (Mouse)
Sequence Position49-54
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Alanine scanning
Interaction ID21072
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20622153
CommentsPhosphorylation of Ser-52 promotes the interaction between the mouse Homeobox protein Nanog and the mouse Peptidyl-prolyl cis-trans isomerase Pin1, leading to Nanog stabilization by suppressing its ubiquitination

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)