Instance ID11074
Regular Expressionxxx([ST])Px
Motif InstanceSDSSPS
Bait Uniprot AccessionP35210
Bait Uniprot IdentifierSPT23_YEAST
Bait Gene NameSPT23
Bait OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Sequence Position651-656
Critical ResiduesP4; P5
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Phosphatase assay; Pull down; Alanine scanning
Interaction ID21074
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19597489
CommentsThe yeast peptidyl-prolyl cis/trans isomerase Pin1 (Ess1) is essential for viability because it controls the NF-kappaB-related Spt23 transcription factor involved in unsaturated fatty-acid synthesis via an interaction with phosphorylated Ser-654 of Spt23

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)