Instance ID11075
Regular Expressionxxx([ST])Px
Motif InstanceNVLSPL
Bait Uniprot AccessionP04637
Bait Uniprot IdentifierP53_HUMAN
Bait Gene NameTP53
Bait OrganismHomo sapiens (Human)
Sequence Position30-35
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Pull down; Mutation analysis
Interaction ID21075
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12388558
CommentsDNA damage enhances the interaction between human Peptidyl-prolyl cis-trans isomerase PIN1 and Cellular tumor antigen TP53 mediated by the WW domain in PIN1 and Ser(33)-Pro motif in TP53, whereby PIN1 regulates the stability of TP53 and its transcriptional activity towards the p21 promoter

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)