Instance ID11076
Regular Expressionxxx([ST])Px
Motif InstancePVKSPH
Bait Uniprot AccessionQ9Y6H5
Bait Uniprot IdentifierSNCAP_HUMAN
Bait Gene NameSNCAIP
Bait OrganismHomo sapiens (Human)
Sequence Position212-217
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Mutation analysis; Classical fluorescence spectroscopy; Phosphatase assay; Pull down
Interaction ID21076
Interacting DomainWW domain
Disease Association(s)Parkinson disease
Inhibitor(s)Unknown
Reference(s)16365047
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-215-Pro motif of human Synphilin-1 (SNCAIP), an alpha-synuclein partner, and enhances its interaction with alpha-synuclein, thus likely facilitating the formation of alpha-synuclein inclusions

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)