Instance ID11077
Regular Expressionxxx([ST])Px
Motif InstancePVLSPM
Bait Uniprot AccessionO15350
Bait Uniprot IdentifierP73_HUMAN
Bait Gene NameTP73
Bait OrganismHomo sapiens (Human)
Sequence Position409-414
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Phosphatase assay; Mutation analysis; Pull down; Co-IP
Interaction ID21077
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)15175157
CommentsThe phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Ser(412)-Pro motif in human Tumor protein TP73 is essential for activation of the apoptotic response by endogenous P73

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)