Instance ID11080
Regular Expressionxxx([ST])Px
Motif InstanceVEQTPK
Bait Uniprot AccessionP46527
Bait Uniprot IdentifierCDN1B_HUMAN
Bait Gene NameCDKN1B
Bait OrganismHomo sapiens (Human)
Sequence Position184-189
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Fluorescence technology; Co-IP; Mutation analysis
Interaction ID21080
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19584057
CommentsThe phosphorylation-dependent interaction between the WW domain of human Peptidyl-prolyl cis-trans isomerase PIN1 and Thr(187)-Pro motif in human Cyclin-dependent kinase inhibitor p27 (CDKN1B) catalyzes the cis-trans conformational changes of KIP1 and mediates its stability through the polyubiquitination mechanism

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)