Instance ID11081
Regular Expressionxxx([ST])Px
Motif InstanceLACTPT
Bait Uniprot AccessionP25322
Bait Uniprot IdentifierCCND1_MOUSE
Bait Gene NameCcnd1
Bait OrganismMus musculus (Mouse)
Sequence Position283-288
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Pull down; Mutation analysis
Interaction ID21081
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11805292
CommentsMouse Peptidyl-prolyl cis-trans isomerase Pin1 directly binds to mouse G1/S-specific cyclin-D1 phosphorylated on Thr-286-Pro, thereby positively regulating cyclin-D1 function at the transcriptional level

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)