Instance ID11086
Regular Expressionxxx([ST])Px
Motif InstanceGPPSPR
Bait Uniprot AccessionP29590
Bait Uniprot IdentifierPML_HUMAN
Bait Gene NamePML
Bait OrganismHomo sapiens (Human)
Sequence Position524-529
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Phosphatase assay; Pull down; Mutation analysis
Interaction ID21086
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)18039859
CommentsDegradation of the human tumor suppressor Promyelocytic leukemia protein (PML) by human Peptidyl-prolyl cis-trans isomerase PIN1, in a phosphorylation-dependent manner via the Ser-527-Pro motif in PML, contributes to the oncogenic transformation and cancer phenotype

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)