Instance ID11091
Regular Expressionxxx([ST])Px
Motif InstanceLGGTPT
Bait Uniprot AccessionP46531
Bait Uniprot IdentifierNOTC1_HUMAN
Bait Gene NameNOTCH1
Bait OrganismHomo sapiens (Human)
Sequence Position2129-2134
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Western blot; Pull down; Co-IP; Alanine scanning
Interaction ID21091
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19151708
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-2132-Pro motif of human NOTCH1, thereby enhancing NOTCH1 transcriptional and tumorigenic activity

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)