Instance ID11097
Regular Expressionxxx([ST])Px
Motif InstanceYQLSPP
Bait Uniprot AccessionP03409
Bait Uniprot IdentifierTAX_HTL1A
Bait Gene Nametax
Bait OrganismHuman T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
Sequence Position157-162
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Alanine scanning; Pull down
Interaction ID21097
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19338781
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein by interacting with its phosphorylated Ser160-Pro motif and thereby promotes malignant transformation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)