Instance ID11104
Regular Expressionxxx([ST])Px
Motif InstanceITITPP
Bait Uniprot AccessionP31749
Bait Uniprot IdentifierAKT1_HUMAN
Bait Gene NameAKT1
Bait OrganismHomo sapiens (Human)
Sequence Position447-452
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Competition binding; Co-IP; Pull down; Alanine scanning
Interaction ID21104
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19448664
CommentsThe human oncogenic Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-450-Pro motif of human serine/threonine Protein kinase B alpha (PKB alpha, also known as AKT1/Proto-oncogene c-Akt) to protect Akt from degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)