Instance ID11112
Regular Expressionxxx([ST])Px
Motif InstanceSAKTPG
Bait Uniprot AccessionQ9NY61
Bait Uniprot IdentifierAATF_HUMAN
Bait Gene NameAATF
Bait OrganismHomo sapiens (Human)
Sequence Position143-148
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Phosphatase assay; Co-IP; Pull down; Alanine scanning
Interaction ID21112
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17468107
CommentsIn response to apoptotic stimuli, human Peptidyl-prolyl cis-trans isomerase PIN1 binds the phosphorylated Thr-146-Pro motif of human Rb-binding protein CHE1/AATF and affects its stability by increasing its capacity to interact with HDM2

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)