Instance ID11113
Regular Expressionxxx([ST])Px
Motif InstanceERITPL
Bait Uniprot AccessionP54274
Bait Uniprot IdentifierTERF1_HUMAN
Bait Gene NameTERF1
Bait OrganismHomo sapiens (Human)
Sequence Position146-151
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Phosphatase assay; Co-IP; Pull down; Alanine scanning
Interaction ID21113
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19060891
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr149–Pro motif in the human Telomeric protein Pin2/TRF1 in a phosphorylation-dependent and mitosis-specific manner and acts as an essential regulator of TRF1 stability, telomere maintenance and ageing

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)