Instance ID11116
Regular Expressionxxx([ST])Px
Motif InstancePNLSPN
Bait Uniprot AccessionP84022
Bait Uniprot IdentifierSMAD3_HUMAN
Bait Gene NameSMAD3
Bait OrganismHomo sapiens (Human)
Sequence Position205-210
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Alanine scanning
Interaction ID21116
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19122240
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-208-Pro motif of human SMAD3 thereby inducing its degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)