Instance ID11117
Regular Expressionxxx([ST])Px
Motif InstanceAAPTPA
Bait Uniprot AccessionP04637
Bait Uniprot IdentifierP53_HUMAN
Bait Gene NameTP53
Bait OrganismHomo sapiens (Human)
Sequence Position78-83
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Pull down; Alanine scanning
Interaction ID21117
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12397362
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-81-Pro motif of human Cellular tumor antigen TP53 and is involved in the regulation of its stability and transcriptional activities

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)