Instance ID11120
Regular Expressionxxx([ST])Px
Motif InstanceKKTSPL
Bait Uniprot AccessionP35991
Bait Uniprot IdentifierBTK_MOUSE
Bait Gene NameBtk
Bait OrganismMus musculus (Mouse)
Sequence Position18-23
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Alanine scanning
Interaction ID21120
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16644721
CommentsMouse Peptidyl-prolyl cis-trans isomerase Pin1 binds to the Ser-21-Pro motif of mouse Tyrosine-protein kinase Btk in a cell cycle-dependent manner, thereby regulating the Btk expression level

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)