Instance ID11131
Regular Expressionxxx([ST])Px
Motif InstanceYGSSPC
Bait Uniprot AccessionP35568
Bait Uniprot IdentifierIRS1_HUMAN
Bait Gene NameIRS1
Bait OrganismHomo sapiens (Human)
Sequence Position431-436
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Pull down; Co-IP; Alanine scanning; Mutation analysis
Interaction ID21131
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)21454638
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphoserine 434-containing motif in human Insulin receptor substrate 1 (IRS1) through its WW domain and enhances insulin actions and adipogenesis

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)