Instance ID11136
Regular Expressionxxx([ST])Px
Motif InstanceLPMSPR
Bait Uniprot AccessionP40763
Bait Uniprot IdentifierSTAT3_HUMAN
Bait Gene NameSTAT3
Bait OrganismHomo sapiens (Human)
Sequence Position724-729
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Pull down; Co-IP; Alanine scanning
Interaction ID21136
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17563747
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Ser-727-Pro motif of human Acute-phase response factor STAT3 upon cytokine/growth factor stimulation and promotes STAT3 transcriptional activity

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)