Instance ID11139
Regular Expressionxxx([ST])Px
Motif InstancePPLSPP
Bait Uniprot AccessionQ8BUV3
Bait Uniprot IdentifierGEPH_MOUSE
Bait Gene NameGphn
Bait OrganismMus musculus (Mouse)
Sequence Position191-196
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Phosphatase assay; Co-IP; Pull down; Mutation analysis
Interaction ID21139
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17347650
CommentsThe Mouse microtubule binding protein Gephyrin (Gphn) undergoes proline-directed phosphorylation, which is followed by the recruitment of the Mouse Peptidyl-prolyl cis-trans isomerase Pin1 through the Ser-194-Pro motif, which triggers conformational changes in the Gephyrin molecule, thus enhancing its ability to bind the beta subunit of glycine receptors

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)