Instance ID11143
Regular Expressionxxx([ST])Px
Motif InstanceLVRSPQ
Bait Uniprot AccessionP46531
Bait Uniprot IdentifierNOTC1_HUMAN
Bait Gene NameNOTCH1
Bait OrganismHomo sapiens (Human)
Sequence Position2118-2123
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Far Western blotting; Western blot; Co-IP; Pull down(GST tag); Alanine scanning
Interaction ID21143
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)19151708
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds directly to human NOTCH1 at the Ser-2121-Pro motif and regulates its activity, cooperating with NOTCH1 in tumorigenesis

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)