Instance ID11149
Regular Expressionxxx([ST])Px
Motif InstanceVFRTPP
Bait Uniprot AccessionQ04206
Bait Uniprot IdentifierTF65_HUMAN
Bait Gene NameRELA
Bait OrganismHomo sapiens (Human)
Sequence Position251-256
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Alanine scanning
Interaction ID21149
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)14690596
CommentsUpon cytokine treatment, human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Thr-254-Pro motif in human Nuclear factor NF-kappa-B p65 subunit (RELA) and inhibits p65 binding to I-kappa-B-alpha, resulting in increased nuclear accumulation and protein stability of p65 and enhanced NF-kappa-B activity

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)