Instance ID11156
Regular Expressionxxx([ST])Px
Motif InstanceASQSPR
Bait Uniprot AccessionQ9UER7
Bait Uniprot IdentifierDAXX_HUMAN
Bait Gene NameDAXX
Bait OrganismHomo sapiens (Human)
Sequence Position175-180
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4
Secondary StructureUnknown
Experimental Method(s)Phosphatase assay; Pull down; Mutation analysis; Co-IP
Interaction ID21156
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)17938171
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 binds to the phosphorylated Ser-178-Pro motif in the human Death domain-associated protein 6 (DAXX) and plays an important role in the negative regulation of DAXX, thereby inhibiting the oxidative stress-induced cellular apoptotic response

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)