Instance ID11157
Regular Expressionxxx([ST])Px
Motif InstanceSPSTPS
Bait Uniprot AccessionP22736
Bait Uniprot IdentifierNR4A1_HUMAN
Bait Gene NameNR4A1
Bait OrganismHomo sapiens (Human)
Sequence Position140-145
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Alanine scanning; Pull down(GST tag)
Interaction ID21157
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)22002310
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 stabilizes and activates human Orphan nuclear receptor TR3 (NR4A1) through its phosphorylated Thr-143-Pro motif to promote mitogenesis and tumor growth

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)