Instance ID11159
Regular Expressionxxx([ST])Px
Motif InstanceCSATPT
Bait Uniprot AccessionQ969H0
Bait Uniprot IdentifierFBXW7_HUMAN
Bait Gene NameFBXW7
Bait OrganismHomo sapiens (Human)
Sequence Position202-207
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Thr-P4
Secondary StructureUnknown
Experimental Method(s)Co-IP; Pull down; Mutation analysis
Interaction ID21159
Interacting DomainWW domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)22608923
CommentsThe human Peptidyl-prolyl cis-trans isomerase PIN1 interacts with the phosphorylated Thr-205-Pro motif of human F-box protein FBXW7, the substrate recognition component of the SCF E3 ligase complex, and promotes Fbw7 self-ubiquitination and protein degradation, thereby negatively regulating its tumor suppressor function

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)