Instance ID11169
Regular Expressionxx(T)xx[DE]x
Motif InstanceESTDEES
Bait Uniprot AccessionQ13426
Bait Uniprot IdentifierXRCC4_HUMAN
Bait Gene NameXRCC4
Bait OrganismHomo sapiens (Human)
Sequence Position231-237
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Thr-P3
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag); ITC; Fluorescence polarization spectroscopy
Interaction ID21169
Interacting DomainFHA domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15385968
CommentsHuman Bifunctional polynucleotide phosphatase/kinase PNKP functions in Nonhomologous end joining (NHEJ) via an FHA domain-dependent interaction with a phosphothreonine motif of human DNA repair protein XRCC4

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)