Instance ID11194
Regular ExpressionxF[^P][^P][KRIL]H[^P][^P][YLMFH][^P]xxx
Motif InstancePFARLHECYGQEI
Bait Uniprot AccessionQ8N4B1
Bait Uniprot IdentifierSESQ1_HUMAN
Bait Gene NameFAM109A
Bait OrganismHomo sapiens (Human)
Sequence Position223-235
Critical ResiduesP2; P6
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation disrupting interaction; X-ray crystallography; ITC; SPR; Y2H; Co-IP; Pull down(GST tag); Colocalization; Competition binding
Interaction ID21194
Interacting DomainASH-RhoGAP-like domain
Disease Association(s)Lowe syndrome; Dent disease type 2
Inhibitor(s)Unknown
Reference(s)21233288, 20133602, 21666675
CommentsThe conserved F and H motif in human Sesquipedalian-1 (FAM109A/IPIP27A) that binds to the ASH-RhoGAP-like domain of human OCRL1


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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)