Instance ID11195
Regular ExpressionxF[^P][^P][KRIL]H[^P][^P][YLMFH][^P]xxx
Motif InstanceCFSTLHDWYGQEI
Bait Uniprot AccessionQ6ICB4
Bait Uniprot IdentifierSESQ2_HUMAN
Bait Gene NameFAM109B
Bait OrganismHomo sapiens (Human)
Sequence Position223-235
Critical ResiduesP2; P6
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation disrupting interaction; Y2H; Co-IP; Pull down(GST tag); ITC; SPR; Colocalization; Competition binding
Interaction ID21195
Interacting DomainASH-RhoGAP-like domain
Disease Association(s)Lowe syndrome; Dent disease type 2
Inhibitor(s)Unknown
Reference(s)21233288, 20133602, 21666675
CommentsThe conserved F and H motif in human Sesquipedalian-2 (FAM109B/IPIP27B) that binds to the ASH-RhoGAP-like domain of human OCRL1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)