Instance ID11196
Regular ExpressionxF[^P][^P][KRIL]H[^P][^P][YLMFH][^P]xxx
Motif InstanceSFQQRHESLRPAA
Bait Uniprot AccessionQ9UKG1
Bait Uniprot IdentifierDP13A_HUMAN
Bait Gene NameAPPL1
Bait OrganismHomo sapiens (Human)
Sequence Position403-415
Critical ResiduesP2; P6
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation disrupting interaction; Sequence based prediction; Co-IP; Pull down(GST tag); ITC; SPR; Colocalization; Competition binding
Interaction ID21196
Interacting DomainASH-RhoGAP-like domain
Disease Association(s)Lowe syndrome
Inhibitor(s)Unknown
Reference(s)21233288, 18307981, 17765681, 20133602, 21666675
CommentsThe conserved F and H motif in human DCC-interacting protein 13-alpha (DIP13A/APPL1) that binds to the ASH-RhoGAP-like domain of human OCRL1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)