Instance ID11207
Regular ExpressionWxP
Motif InstanceWFP
Bait Uniprot AccessionQ01705
Bait Uniprot IdentifierNOTC1_MOUSE
Bait Gene NameNotch1
Bait OrganismMus musculus (Mouse)
Sequence Position1758-1760
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)ITC; MASLS; Cross-linking experiments; Comigration in gel electrophoresis
Interaction ID21207
Interacting DomainBeta-trefoil domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17070841, 20028974
CommentsThe conserved WFP sequence motif within the RAM region (the approximately 140 residue polypeptide segment N-terminal to the ANK domain) of mouse Notch1 protein that mediates binding to the beta trefoil domain (or BTD) of human CSL (RBPJ)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)