Instance ID11215
Regular ExpressionPPPYx{4,4}[ST][ILV]
Motif InstancePPPYPTDCSI
Bait Uniprot AccessionQ9H3D4
Bait Uniprot IdentifierP63_HUMAN
Bait Gene NameTP63
Bait OrganismHomo sapiens (Human)
Sequence Position540-549
Critical ResiduesP1; P2; P4; P10
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)NMR; CD; Fluorescence
Interaction ID21215
Interacting DomainWW domain
Disease Association(s)Hay-Wells syndrome
Inhibitor(s)Unknown
Reference(s)20855944
CommentsHuman E3 ubiquitin-protein ligase ITCH, a group I WW domain protein, and human Tumor protein TP63 interact with each other through the WW2 domain and the consensus PPxY or PY motif and this interaction is crucial for p63 degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)