Instance ID11216
Regular ExpressionPPPYx{4,4}[ST][ILV]
Motif InstancePPPYPTDCSI
Bait Uniprot AccessionO88898
Bait Uniprot IdentifierP63_MOUSE
Bait Gene NameTp63
Bait OrganismMus musculus (Mouse)
Sequence Position540-549
Critical ResiduesP1; P2; P4; P10
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)NMR; CD; Fluorescence
Interaction ID21216
Interacting DomainWW domain
Disease Association(s)Hay-Wells syndrome
Inhibitor(s)Unknown
Reference(s)20855944
CommentsMouse E3 ubiquitin-protein ligase Itch, a group I WW domain protein, and mouse Tumor protein Tp63 interact with each other through the WW2 domain and the consensus PPxY or PY motif and this interaction is crucial for p63 degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)