Instance ID11268
Regular Expression[KR]xTQTx
Motif InstanceKQTQTT
Bait Uniprot AccessionQ24246
Bait Uniprot IdentifierDYIN_DROME
Bait Gene Namesw
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position130-135
Critical ResiduesP1; P3; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; NMR; pull down(GST tag); protection from proteolytic digestion; Far-UV CD spectropolarimetry; EMSA; Fluorescence Spectroscopy
Interaction ID21268
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17570393, 15581372
CommentsThe N-terminal domain of Drosophila Cytoplasmic dynein 1 intermediate chain (sw), is highly disordered, but upon binding to Drosophila cytoplasmic dynein light-chain subunit LC8 (or ctp), it undergoes a significant conformational change to a more ordered structure

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)