Instance ID11305
Regular Expression[DS]Kx[TVI]Q[TV][DE]
Motif InstanceTKETQTP
Bait Uniprot AccessionQ13409
Bait Uniprot IdentifierDC1I2_HUMAN
Bait Gene NameDYNC1I2
Bait OrganismHomo sapiens (Human)
Sequence Position157-163
Critical ResiduesP1; P3; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; NMR; protection from proteolytic digestion; pull down(GST tag); EMSA; Fluorescence Spectroscopy
Interaction ID21305
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17551010, 16949604, 15581372
CommentsThe N-terminal domain of human Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) is a highly disordered monomer but gains helical structure upon binding to Drosophila cytoplasmic dynein light-chain subunit LC8 (or ctp)

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)