Instance ID11340
Regular ExpressionSxxF
Motif InstanceSPTF
Bait Uniprot AccessionQ9BX63
Bait Uniprot IdentifierFANCJ_HUMAN
Bait Gene NameBRIP1
Bait OrganismHomo sapiens (Human)
Sequence Position990-993
Critical ResiduesP1; P4
Motif PTM(s)Phosphorylation at Ser-P1
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; NMR; Site-directed Mutagenesis; SPR; ITC
Interaction ID21340
Interacting DomainBRCT domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)15133503, 15133502, 15242590, 14576433
CommentsMotif mediating phosphorylation-dependent BRCA1-BACH1 interaction essential for G2 accumulation checkpoint control of the cell cycle

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)