Instance ID11341
Regular ExpressionSxxF
Motif InstanceSPVF
Bait Uniprot AccessionQ99708
Bait Uniprot IdentifierCOM1_HUMAN
Bait Gene NameRBBP8
Bait OrganismHomo sapiens (Human)
Sequence Position327-330
Critical ResiduesP1; P4
Motif PTM(s)Phosphorylation at Ser-P1
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Mutational analysis; Sequence based prediction; ITC
Interaction ID21341
Interacting DomainBRCT domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)16101277, 15485915, 14578343
CommentsMotif mediating phosphorylation-dependent BRCA1-CtIP interaction essential for G2/M transition checkpoint control of the cell cycle

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)