Instance ID11422
Regular ExpressionLxxLL
Motif InstanceLHRLL
Bait Uniprot AccessionQ15596
Bait Uniprot IdentifierNCOA2_HUMAN
Bait Gene NameNCOA2
Bait OrganismHomo sapiens (Human)
Sequence Position690-694
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography; SPR; Mutational analysis
Interaction ID21422
Interacting DomainAF-2 transcriptional activation domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11937504
CommentsNR Box B2 region (690-694) of human Nuclear receptor coactivator 2 required for the ligand-dependent binding to the AF-2 transcriptional activation domain of human Estrogen receptor

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)