Instance ID11441
Regular ExpressionLxxLL
Motif InstanceLHKLL
Bait Uniprot AccessionQ9Y6Q9
Bait Uniprot IdentifierNCOA3_HUMAN
Bait Gene NameNCOA3
Bait OrganismHomo sapiens (Human)
Sequence Position685-689
Critical ResiduesP4; P5
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography; Mutational analysis; Competition binding assay; Mammalian two-hybrid assay
Interaction ID21441
Interacting DomainAF-2 transcriptional activation domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)20086010
CommentsCore LXXLL motif sequence (NR Box I) in SRC3/AIB1/NCOA3 required for the ligand-dependent binding to the Androgen receptor(AR) & this functional relationship between AR and SRC3 leads to the development and growth of prostate cancer.

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)