Instance ID11442
Regular ExpressionLxxLL
Motif InstanceLHTLL
Bait Uniprot AccessionQ9Y6Q9
Bait Uniprot IdentifierNCOA3_HUMAN
Bait Gene NameNCOA3
Bait OrganismHomo sapiens (Human)
Sequence Position1057-1061
Critical ResiduesP4; P5
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)X-ray crystallography; Mutational analysis; Competition binding assay; Mammalian two-hybrid assay
Interaction ID21442
Interacting DomainAF-2 transcriptional activation domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)20086010
CommentsCore LXXLL motif sequence (NR Box III) in SRC3/AIB1/NCOA3 required for the ligand-dependent binding to the Androgen receptor(AR) & this functional relationship between AR and SRC3 leads to the development and growth of prostate cancer.

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)