Instance ID11443
Regular ExpressionLxxLL
Motif InstanceLHKLL
Bait Uniprot AccessionQ9Y6Q9
Bait Uniprot IdentifierNCOA3_HUMAN
Bait Gene NameNCOA3
Bait OrganismHomo sapiens (Human)
Sequence Position685-689
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mammalian two-hybrid assay
Interaction ID21443
Interacting DomainAF-2 transcriptional activation domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)20086010
CommentsCore LXXLL motif sequence (NR Box I) in SRC3/AIB1/NCOA3 required for the ligand-dependent binding to the Estrogen receptor(ER-alpha), which may serve as the physical basis for functional coupling of these two proteins for breast cancer development and progression.

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)