Instance ID11464
Regular ExpressionFxxLF
Motif InstanceFQNLF
Bait Uniprot AccessionP10275
Bait Uniprot IdentifierANDR_HUMAN
Bait Gene NameAR
Bait OrganismHomo sapiens (Human)
Sequence Position23-27
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Mammalian two-hybrid assay; GST interaction assay
Interaction ID21464
Interacting DomainAF-2 transcriptional activation domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10816582
CommentsThe FXXLF sequence in the N-terminal domain of Androgen receptor(AR), the predominant androgen-dependent interaction site, that interacts with AF2 and mediates a direct interaction between the N-terminal and C-terminal regions of AR to stabilize the hormone-receptor complex for AR-mediated transcriptional activation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)