Instance ID11490
Regular Expression[ST]x[VL]$
Motif InstanceTKV
Bait Uniprot AccessionP60484
Bait Uniprot IdentifierPTEN_HUMAN
Bait Gene NamePTEN
Bait OrganismHomo sapiens (Human)
Sequence Position401-403
Critical ResiduesP2; P3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down(GST tag); Y2H
Interaction ID21490
Interacting DomainPDZ domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)10748157, 15951562
CommentsC-terminal tail of PTEN that interacts with the PDZ domain 2 of MAGI3 to position PTEN phosphatase to specific subcellular locations that are involved with the regulation of cell proliferation and survival

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)