Instance ID11498
Regular Expression[ST]x[VL]$
Motif InstanceTQL
Bait Uniprot AccessionP03126
Bait Uniprot IdentifierVE6_HPV16
Bait Gene NameE6
Bait OrganismHuman papillomavirus type 16
Sequence Position156-158
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)SPR; Mutational analysis; Pull down(GST tag); In vitro-degradation assay
Interaction ID21498
Interacting DomainPDZ domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)20842623, 11077444
CommentsC-terminal sequences in E6 oncoprotein of Human papillomavirus type 16 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)