Instance ID11499
Regular Expression[ST]x[VL]$
Motif InstanceTQV
Bait Uniprot AccessionP06463
Bait Uniprot IdentifierVE6_HPV18
Bait Gene NameE6
Bait OrganismHuman papillomavirus type 18
Sequence Position156-158
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; SPR; Mutational analysis; Pull down(GST tag); In vitro degradation assay
Interaction ID21499
Interacting DomainPDZ domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)20842623, 17267502, 11077444
CommentsC-terminal sequences in E6 oncoprotein of Human papillomavirus type 18 carrying the consensus PDZ-binding motif which binds to the PDZ1 domain of MAGI-1 (MAGuK inverted protein 1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)