Instance ID11505
Regular Expression[ST]x[VL]$
Motif InstanceTLV
Bait Uniprot AccessionP89079
Bait Uniprot IdentifierE4OR1_ADE09
Bait Gene NameE4
Bait OrganismHuman adenovirus D serotype 9 (HAdV-9) (Human adenovirus 9)
Sequence Position123-125
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)SPR; Mutational analysis
Interaction ID21505
Interacting DomainPDZ domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)20842623, 11077444
CommentsC-terminal PDZ domain-binding motif in the Ad9 E4-ORF1 oncoprotein which bind to PDZ1 and PDZ3 of MAGI-1 and inhibit its function in cells by aberrantly sequestering it to the cytoplasm

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)