Instance ID11512
Regular Expression[ST]x[VL]$
Motif InstanceTQL
Bait Uniprot AccessionP03126
Bait Uniprot IdentifierVE6_HPV16
Bait Gene NameE6
Bait OrganismHuman papillomavirus type 16
Sequence Position156-158
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down; Co-IP
Interaction ID21512
Interacting DomainPDZ domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)9326658, 10523825
CommentsC terminal binding motif of E6 oncoprotein of Human papillomavirus type 16 that binds to the second PDZ domain of DLG and causes a dramatic reduction in the levels of DLG expression by targeting it for proteasome mediated degradation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)