Instance ID11523
Regular Expression[ST]x[VL]$
Motif InstanceTQL
Bait Uniprot AccessionP03126
Bait Uniprot IdentifierVE6_HPV16
Bait Gene NameE6
Bait OrganismHuman papillomavirus type 16
Sequence Position156-158
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21523
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11027293
CommentsPDZ binding epitope of E6 oncoprotein of Human papillomavirus type 16 that mediates its binding to the human homolog of the Drosophila PDZ domain-containing tumor suppressor protein Scribble, hScrib, which is associated with cell junction complexes

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)