Instance ID11526
Regular Expression[ST]x[VL]$
Motif InstanceTQL
Bait Uniprot AccessionP03126
Bait Uniprot IdentifierVE6_HPV16
Bait Gene NameE6
Bait OrganismHuman papillomavirus type 16
Sequence Position156-158
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21526
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16878151
CommentsPDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 that binds to and promotes the degradation of CAL (GOPC) through the ubiquitin-proteasome pathway

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)