Instance ID11527
Regular Expression[ST]x[VL]$
Motif InstanceTQV
Bait Uniprot AccessionP06463
Bait Uniprot IdentifierVE6_HPV18
Bait Gene NameE6
Bait OrganismHuman papillomavirus type 18
Sequence Position156-158
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21527
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16878151
CommentsPDZ binding motif in E6 oncoprotein of Human papillomavirus type 18 that binds to and promotes the degradation of CAL (GOPC) through the ubiquitin-proteasome pathway

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)