Instance ID11528
Regular Expression[ST]x[VL]$
Motif InstanceTQL
Bait Uniprot AccessionP03126
Bait Uniprot IdentifierVE6_HPV16
Bait Gene NameE6
Bait OrganismHuman papillomavirus type 16
Sequence Position156-158
Critical ResiduesP3
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21528
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)17166906, 15492812
CommentsPDZ binding motif in E6 oncoprotein of Human papillomavirus type 16 which mediates the binding and degradation of the protein tyrosine phosphatase PTPN3 (PTPH1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)